DISSECTING THE MOLECULAR MECHANISMS OF GENE X ENVIRONMENT INTERACTIONS: IMPLICATIONS FOR DIAGNOSIS AND TREATMENT OF STRESS-RELATED PSYCHIATRIC DISORDERS

Epidemiological studies indicate a combined contribution of genetic and environmental factors, mainly exposure to adverse life events, in the risk for psychiatric disease.Understanding how adverse life events interact with genetic predisposition on the molecular level to shape risk and resilience to psychiatric disorders may yield important insight

Background Proliferation of malignant plasma cells is a strong adverse prognostic factor in multiple myeloma and simultaneously targetable by available (e.g.tubulin polymerase inhibitors) and upcoming (e.g.aurora kinase inhibitors) compounds.Design and Methods We assessed proliferation using gene expression-based indices in 757 samples including in

The paper addresses the issue of the proliferation of the rocket technology deployed in guerrilla warfare throughout the Near East.It evaluates assumptions and identifies potential regressions with respect to the Learning Tower most recent hot phase in the violent conflict between Hezbollah and Israel, with a focus on primary methods based on rocke

Electron beam melting (EBM) additive manufacturing (AM) has grown rapidly in recent years due to its capability to manufacture high-performance metals and conductive ceramics.Whereas in-situ synchrotron X-ray imaging and diffraction have proven invaluable tools in understanding of laser powder bed fusion (L-PBF), the characterization of the EBM pro